Central Carbons Targeted Panel
Rigorous Quality Control
About Central Carbon Metabolism
Metabolomics reveals biological insights otherwise unseen. For a successful metabolomics study, both small molecule discovery and the ability to dig deeper into specific biomarkers of interest are needed to uncover actionable insights that propel new therapeutic developments. A specific combination of liquid chromatography-mass spectrometry (LC-MS) technology and biochemical expertise is required to identify these biomarkers of interest and develop assays that are sensitive enough to explore them fully.
At Metabolon, we understand the crucial role central carbon metabolites play in cellular processes, and we’ve established best-in-class expertise for their detection. This panel focuses on specific central carbon metabolites and their metabolic pathways and can be used to track biomarkers and enhance biological understanding across preclinical and clinical research.
Central Carbons Targeted Panel Details
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|Lactic Acid||40.0 µg/mL||40.0 µg/mL|
|Pyruvic Acid||0.500 µg/mL||0.500 µg/mL|
|Citric Acid||5.00 µg/mL||5.00 µg/mL|
|2-Ketoglutaric Acid||0.500 µg/mL||0.500 µg/mL|
|Succinic Acid||0.100 µg/mL||0.100 µg/mL|
|Malic Acid||0.0500 µg/mL||0.0500 µg/mL|
|Fumaric Acid||0.100 µg/mL||0.100 µg/mL|
Analysis Method and Instrumentation
LC-MS/MS (Agilent 1290 UHPLC/Sciex QTrap 5500)
|Sample Type and Required Amounts|
|Sample Type||Sample Requirements|
|Plasma/Serum||100 to 150 µL|
|Cell cultures||300 to 500 µL|
|Tissue||50 to 100 mg|
Disclaimer: This method is for Research Use Only and is not to be used for diagnostic purposes.
Delivering Absolute Quantification for Research and Biomarker Analysis
Our readily available or custom developed quantitative assays help you achieve your research and biomarker validation objectives with precise and fully validated methods. Our targeted assays and panels cover >1,000 metabolites and lipids across a wide range of biochemical classes, metabolic pathways, and physiological processes, and they can be customized to best fit any application.
Central Carbons Targeted Panel Applications
Metabolomics enables simultaneous assessment of hundreds of compounds present in living systems, making it a critical tool that advances our understanding of disease mechanisms and opens doors to identify novel targets and treatments for conditions like diabetes.
Big Insights with Metabolon
Cited in over 3,000 publications, we help scientists and manufacturers gain greater insight into their studies through metabolomics. See how our approach can become a successful part of your workflow.
Related Metabolomics Resources
Talk with an expert
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617 Davis Drive, Suite 100
Morrisville, NC 27560
P.O. Box 110407
Research Triangle Park, NC 27709
+1 (919) 572-1711