Immuno-Oncology Therapy is a Targeted Answer to Cancer
Cancer is the second highest cause of death worldwide and is associated with approximately 10 million deaths per year.1 To alleviate cancer outcomes, various types of therapeutic agents continue to be developed. Although traditional treatments like chemotherapy and radiation have been the prevalent option for cancer treatment, the development of immuno-oncology therapies can provide high specificity and longer-lasting remissions.2
Immuno-oncology therapies harness the power of the host’s immune system to prevent, control, and eliminate cancer. The role of the immune system is to eliminate potential threats to our health. The system works well, but cancer cells sometimes slip past this mechanism. Immuno-oncology is an emerging field that enables the host’s immune system to better recognize and target cancer cells.
Predictive Biomarkers are Required for Better Patient Stratification
A Better Understanding of Cancer Immunotherapy
Metabolomics can find predictive biomarkers and targets for manipulating the host immune response. Host-related factors have long been overlooked in favor of cancer-related factors in oncology. Metabolon’s metabolomics technology provides a reproducible analysis of a sample’s metabolomic profile, which may lead to the identification of metabolic signatures that are unique to successful immuno-oncology treatments. This metabolic signature could have application as a predictor of response to cancer immunotherapy.
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See how Metabolon can advance your path to preclinical and clinical insights
Metabolomics Panels for Immuno-Oncology
Amino Acids Targeted Panel
Bile Acids Targeted Panel
Central Carbons Targeted Panel
Free Fatty Acids Targeted Panel
Impaired Glucose Tolerance Targeted Panel
Impaired Glucose Tolerance can be assessed with a single fasted blood draw by measuring a panel of selected metabolites comprised of two small organic acids (α-hydroxybutyric acid (AHB) and 4-methyl-2-oxopentanoic acid (4MOP)), 2 lipids (oleic acid and linoleoyl glycerophosphocholine (LGPC)), a ketone body (β-hydroxybutyric acid (BHBA)), an amino acid (serine), a vitamin (pantothenic acid (vitamin B5)), and glucose.
Metal Analysis Targeted Panel
Tryptophan/Kynurenine Ratio Targeted Panel
The kynurenine pathway is a metabolic pathway leading to the production of nicotinamide adenine dinucleotide (NAD+) from the enzymatic conversion of tryptophan. Immune activation leads to the formation of kynurenine with corresponding loss of tryptophan. The kynurenine/tryptophan ratio has been used to reflect the activity of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in cellular inflammatory response related to symptoms of depression, schizophrenia, and other neurological diseases.
Metabolon in Action
Better Immunotherapy Outcomes by Improving NK Cell Therapy
Cancer Treatment Response Prediction
Interested in Further Studies?
Once you see the full value of metabolomics, the only remaining question is who does it best? While many laboratories have metabolite profiling or analytical chemistry capabilities, comprehensive metabolomics technologies are extremely rare. Accurate, unbiased metabolite identification across the entire metabolome introduces signal-to-noise challenges that very few labs are equipped to handle. Also, translating massive quantities of data into actionable information is slow, if not impossible, for most because proper interpretation takes two things that are in short supply: experience and a comprehensive database.
Only Metabolon has all four core metabolomics capabilities
Ability to interrogate thousands of metabolites across diverse biochemical space, revealing new insights and opportunities
Ability to integrate the data from different studies into the same dataset, in different geographies, among different patients over time
Ability to inform on proper study design, generate high‐quality data, derive biological insights, and make actionable recommendations
Ability to process hundreds of thousands of samples quickly and cost‐efficiently to service rapidly growing demand
Partner with Metabolon to access:
A library of 5,400+ known metabolites, 2,000 in human plasma, all referenced in the context of biochemical pathways
- That’s 5x the metabolites of the closest competitor
Unparalleled depth and breadth of experience analyzing and interpreting metabolomic data to find meaningful results
- 10,000+ projects with hundreds of clients
- 2,000+ publications covering 500 diseases, including numerous peer-reviewed journals such as Cell, Nature and Science
- Nearly 40 PhDs in data science, molecular biology, and biochemistry
Using our robust platform and visualization tools, our experts are uniquely able to tell you more about your molecule and develop assay panels to help you zero in on the results you need.
Related Immuno-Oncology Metabolomics Resources
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