Tryptophan/Kynurenine Ratio Targeted Panel
Rigorous Quality Control
About the Kynurenine Pathway
Metabolomics reveals biological insights otherwise unseen. For a successful metabolomics study, both small molecule discovery and the ability to dig deeper into specific biomarkers of interest are needed to uncover actionable insights that propel new therapeutic developments. A specific combination of liquid chromatography-mass spectrometry (LC-MS) technology and expertise is required to identify these biomarkers of interest and develop assays that are sensitive enough to explore them fully.
At Metabolon, we understand the crucial role that the kynurenine pathway plays in inflammation and neurological diseases, and we’ve established best-in-class expertise for the detection of its intermediates. This panel focuses on specific metabolites and their metabolic pathways and can be used to track biomarkers and enhance biological understanding across preclinical and clinical research.
Tryptophan/Kynurenine Ratio Targeted Panel Details
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|Kynurenine/Tryptophan Ratio Assay||Plasma/Serum|
LC-MS/MS (Agilent 1290 UHPLC/Sciex QTrap 5500)
|Sample Type and Required Amounts|
|Sample Type||Sample Requirements|
|Plasma/Serum||100 to 150 µL|
Disclaimer: This method is for Research Use Only and is not to be used for diagnostic purposes.
Delivering Absolute Quantification for Research and Biomarker Analysis
Our readily available or custom developed quantitative assays help you achieve your research and biomarker validation objectives with precise and fully validated methods. Our targeted assays and panels cover >1,000 metabolites and lipids across a wide range of biochemical classes, metabolic pathways, and physiological processes, and they can be customized to best fit any application.
Tryptophan/Kynurenine Ratio Targeted Panel Applications
The importance of inflammation in the development of multiple diseases- and health-related conditions including neurodegeneration, diabetes, cardiovascular disease, cancer, and inflammatory bowel disease is undisputed. Metabolomics can inform on inflammatory processes by providing a readout of the small molecules of an organism, tissue, biofluid, etc. This allows for direct molecular phenotyping of inflammation beyond the standard protein markers of typical assays. Metabolon offers several targeted assays, including oxysterols, fatty acids, kynurenine/tryptophan, and a range of others (central carbon, glucose tolerance, branched-chain amino acids, β-hydroxybutyrate) that can also inform on overall cardiovascular health that is often linked with inflammatory processes.
Personal Care & Cosmetics
Recognized for our cutting-edge approach to metabolomics, Metabolon has been a valued resource for COVID-19 researchers worldwide. Our actionable metabolomic insights have fueled pivotal and high-profile studies like the National Institute of Allergy and Infectious Diseases (NIAID) IMPACC study research to improve understanding of high-risk patients and the Institute for Systems Biology research to improve understanding of high-risk patients. These and other metabolomics projects with actionable insights at Metabolon are helping get closer to the phenotype and pressing forward on COVID-19 answers.
Big Insights with Metabolon
Cited in over 3,000 publications, we help scientists and manufacturers gain greater insight into their studies through metabolomics. See how our approach can become a successful part of your workflow.
Related Metabolomics Resources
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Morrisville, NC 27560
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Research Triangle Park, NC 27709
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